The longer a person’s telomeres, the greater the risk of cancer and other disorders

Gina Kolata in The New York Times:

The story, as often happens in science, sounded so appealing. Cells have a molecular clock that determines how long they live. If you can just stop the clock, cells can live indefinitely. And the same should go for people, who are, after all, made from cells. Stop the cell clocks and you can remain youthful.

The clocks come in the form of caps on the end of chromosomes — the long twisted strings of DNA carrying the cells’ genes. The caps on chromosomes, called telomeres, are chains of short, repeated segments of DNA. Every time a cell divides, its telomeres get a little shorter, until finally they get so short that the cell dies. “Short telomeres were thought to be bad — people with premature aging syndromes had short telomeres — so, by analogy, long telomeres were thought to be good,” said Dr. Mary Armanios, professor of oncology at Johns Hopkins University School of Medicine and director of the Telomere Center at the medical school’s Sidney Kimmel Comprehensive Cancer Center. “And the longer the better.”

But, of course, nothing in biology is so simple. And a paper published Thursday in the New England Journal of Medicine, with results of a study that Dr. Armanios led, shows that the telomere story is no exception. While short telomeres do lead to health problems, long telomeres lead to health problems of their own. Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease.

More here.



Henry Darger’s Book of Weather Reports

Lytle Shaw at Cabinet Magazine:

From December 31, 1957 until December 31, 1967, the artist and writer Henry Darger (1892–1973) kept a series of six ring-binder notebooks with almost daily entries on the weather in his native Chicago. On the outside cover of the first book, Darger describes the project, with encyclopedic enthusiasm, as a “book of weather reports on temperatures, fair cloudy to clear skies, snow, rain, or summer storms, and winter snows and big blizzards—also the low temperatures of severe cold waves and hot spells of summer.”

Though generally short, the entries abound in peculiarities. Darger is concerned, for instance, as much with periods of continuous temperature as with shifts—“3 to 7 am 57” (10/21/1958). Often up at 3am taking readings, Darger’s descriptive vocabulary also tends toward the moral and anthropomorphic: terms like “unsettled” and “threatening” are as common as “cool” or “hot.” Moreover, as the above epigraph suggests, the weatherman becomes a special figure. Darger’s notebooks can, in fact, frequently be read as an excruciatingly detailed moral account book of how well the weatherman was doing his job.

more here.

Monday, May 8, 2023

Oppenheimer I: “An unctuous, repulsively good little boy”

by Ashutosh Jogalekar

“Oppenheimer, Julius Robert”, by David A. Wargowski, December 7, 2018

This is the first of a series of short pieces on J. Robert Oppenheimer. The others can all be found here. Popular interest in Oppenheimer’s life seems to have peaked this year with the upcoming release of Christopher Nolan’s mainstream film, “Oppenheimer”. Several books about Oppenheimer – and even a popular opera – have come out just in the last two decades. Analogies between Oppenheimer and nuclear weapons and new technologies like AI and gene editing are frequently drawn, sometimes incisively and often misleadingly. Why does this man continue to inspire so much interest? And why now?

My goal is to provide readers who might not want to read a full biography of Oppenheimer with some of the highlights of his life that address these questions and put them in context. Needless to say, this series – which is essentially chronological – is not supposed to be an exhaustive biography and is biased by what I personally think was most interesting about this brilliant, fascinating, complicated man’s life and times.

The physicist Isidor Rabi – a friend who perhaps knew Robert Oppenheimer better than he knew himself – once said that Oppenheimer was a man composed of many shining splinters. That succinct assessment captures the central dilemma of Oppenheimer’s life: identity. It was a dilemma that made him who he was and one that contributed to the myriad problems he faced in his life. I also believe that it was this dilemma that makes him a fascinating man of enduring interest, more interest than many of his contemporaries who were far better-known scientists.

To understand this dilemma it’s worth starting, as it often is, with Oppenheimer’s childhood. The affluent household where Oppenheimer was born and grew up was, in the words of a biographer, “like Ibsen’s Rosmersholm, that aristocratic estate where voices and passions were always subdued, and where children never cried – and when they grew up never laughed.” Read more »

The Ghost in the Machine (Part I): Emergence and Intelligence in Large Language Models

by Ali Minai

Part II of this article can now be read here.

One of the most interesting debates within the larger discussion around large language models (LLMs) such as GPT-4 is whether they are just mindless generators of plausible text derived from their training – sometimes termed “stochastic parrots” – or systems with a spark of real intelligence and “emergent” abilities. In this article, I will try to look at these issues from a complex systems perspective. While this article will focus mainly on large language models (LLMs) such as the GPT systems, I will begin by laying out a more general conceptual framework.

Complexity and Complex Systems

Complex systems are defined as systems that consist of a large number of nonlinearly interacting components with the ability to generate large-scale organization without explicit design or control. This self-organization is the essential feature that distinguishes these systems from other complicated but specifically designed systems such as computers and aircraft. Complex systems are common in the natural world, including everything from galaxies and planets to forest fires and hurricanes, but the most profound examples occur in the domain of life. All living systems from bacteria to humans are complex systems. In more complex organisms, their subsystems are also complex systems, e.g., the brain and the immune system in humans. Ecosystems and ecologies too are complex systems, as are collective systems of living agents from slime molds and insect colonies to human societies and economies. In addition to self-organization, some complex systems – and, in particular, those involving living agents – also have the property of adaptivity, i.e., they can change in response to their environment in ways that enhance their productivity. Crucially, this adaptation too is not controlled explicitly by an external agency but occurs within the system through its interactions with the environment and the consequences of these interactions. These systems are called complex adaptive systems. An example of this is evolving species in changing ecosystems, but one that is more pertinent to the current discussion is the nervous system of complex animals such as humans. This system is embedded in another complex system – the rest of the animal’s body – and that, in turn, is embedded in the complex system that is the rest of the world.

Complexity in the sense defined above has several profound implications. One of these is that a complex system’s behavior is inherently impossible to predict by reductionistic causal analysis, and thus impossible to control by any top-down mechanism. This is because almost all large-scale phenomena – attributes, structures, processes, functions – in the system arise bottom-up from the interaction of a very large number of components – often billions or more, as in the cells of the brain – and can neither be reduced to nor described by the behavior of individual components. This property is called emergence. Read more »

Sweet Truth

by Deanna K. Kreisel (Doctor Waffle Blog)

The first time I came across the “candy bar interiors” quiz, I was not disturbed by how many I got wrong, but rather how many I got right. While a few of the pictured confections were alien to me (Zagnut? who the hell eats a Zagnut? did Charlie Chaplin enjoy one in Modern Times?), I was intimately familiar with enough of the images that I could extrapolate the rest.

I just picked the weirdest and creepiest looking option as the Zagnut. I was correct.

I have been unhealthily obsessed with candy bars for as long as I can remember. My obsession is deep, tender, and gently festering, and I feel ambivalent about stirring up the dead leaves at the bottom of that pool. Even though I have written essays about my consistently abusive mother, my intermittently abusive father, my history of panic disorder, and many other delicate topics, an exploration of my feelings about candy bars feels like the most difficult thing I have ever attempted.

The outside layer of a Zagnut is coconut. Who does that?

My parents were largely uninterested in their children, but every once in a while they made a symbolic stab at parenting by doing something like restricting our food choices or giving us a curfew. They forbade sugary breakfast cereals, soda, candy, and chips of any kind—thus setting us up for an enduring obsession with junk food that I carry with me to this day. Even though I am now in my 50s and wholly in charge of my own snack choices, my stomach still flips over a little at the sight of a potato chip bag or a Chip Ahoy. So salty! So mouthfeely! So naughty. Read more »

Is there something fishy about radiocarbon dating?

by Paul Braterman

England Great Army map.svg
A map of the route taken by the Viking Great Heathen Army. Hel-hama, own work, via Wikipedia

The Vikings started out as raiders, but then, in the way of these things, ended up as rulers, and their influence stretched from Greenland to what is now Russia. They first enter English history in 793, with the sacking of the Monastery of Lindisfarne. By the late 9th century, they were colonising Iceland, and serving as mercenaries to the Emperor of Byzantium. In 862, Vikings under Rurik established themselves in Novgorod, forming the nucleus of what would become Kyivan Rus. In 885, Vikings besieged Paris, and although they were beaten back settled in what is now Normandy (Norman, Northmen). In 865, the Viking Great Heathen Army arrived in England, and a year later, under Ivar the Boneless, captured York, which would remain their capital in England until the defeat of Eric Bloodaxe in at 954.

The Vikings’ goal was to establish themselves as rulers over Anglo-Saxon England, divided at that time into the four kingdoms of Northumbria, East Anglia, Mercia, and Wessex, and in this they were almost successful. After establishing their kingdom in York, they swept south, taking control of East Anglia and killing its king, who had earlier provided them with horses. They then spend the next five years consolidating their hold over what had been the most powerful of the Saxon kingdoms, Mercia, stretching from the Thames to the Humber, whose king took refuge in Paris. The Anglo-Saxon Chronicle tells us that in 873-44, a date that will prove significant for us, the army spend the winter in Repton, then a town of some importance. It then divided, one part going north to consolidate control over York, while the other swept south through Mercia into Wessex, which they effectively overran over the next two years. Read more »

On the use and abuse of the term “fascism” to describe current events

by David J. Lobina

For someone who grew up in the South of Europe but has lived in the UK for the last 20 or so years, and who, moreover, is a sort-of linguist, the recent proliferation of the word “fascism” to refer to certain political events and tendencies in the English-speaking world, especially in the US, is not a little surprising. After all, the people we used to refer to as fascists when I was growing up in Italy and Spain certainly bore a resemblance to classical fascism – some were the descendants of actual fascists, in fact – whereas the guys who get called fascist all the time these days, especially in the US, are nothing like them. And in any case, it was the 1990s then and it is 2023 now, is the term “fascism” still relevant today?[i]

Who were these fascists from my youth, then? If you lived in Italy or Spain in the 1990s and were politically active, you would most certainly run into them sooner or later and there were a couple of dates in the calendar that you needed to look out for, as neo-fascists, to employ a perhaps more appropriate nomenclature, tended to come out to commemorate events such as the so-called March on Rome, on the 27th of October, in Italy, and Francisco Franco’s death, on the 20th of November, in Spain.[ii]

As mentioned, some of these people were the descendants of real fascists, and this is perhaps clearest in the case of the Movimento Sociale Italiano, or MSI (The Italian Social Movement), a political party founded in 1946 by veterans from the so-called Republic of Salò – more properly, the Repubblica Sociale Italiana (The Italian Social Republic), a Nazi puppet state nominally led by Benito Mussolini in his nadir days – and which, in 1994, and under the name of Alleanza Nazionale (The National Alliance), entered the government of Silvio Berlusconi, the business magnate turned politician.[iii] This is to some extent also true of the many offshoots of the original Falange Española (The Spanish Falange), a party that was founded in the 1930s on the model of Mussolini’s Partito Nazionale Fascista (the National Fascist Party), the latter created in 1921. In its latest iteration, the Falange goes by the name of the Falange Española de las JONS.[iv]

The modern versions of these organisations, however, differ greatly from classical fascism, by which I mean Italian fascism from 1922 to 1943 (roughly), as well as from each other, and these differences become a chasm when it comes to US politics. And yet seemingly every other week there is an article out there about how the Republican Party is becoming a fascist party, or about how Donald Trump, Tucker Carlson, or Ron DeSantis are all fascists. Read more »

Eugenics and the Biological Justification of Economic Exploitation in Southern Italy

by Andrea Scrima (excerpt from a work-in-progress)

When they arrived in the U.S., Southern Italians brought with them the sense that they’d been branded as underdogs, that they belonged and would forever belong to a lower class, but the birth of the Italian-American gangster was rooted in attitudes toward the Mezzogiorno that dated back far earlier. After Italy was unified under Vittorio Emanuele II in 1861, a new national government imposed Piedmont’s centralized administrative system on the South, which led to violent rebellion against State authority. Politicians and intellectuals took pains to deflect responsibility for what they saw as the “barbarism” of the Mezzogiorno, and were particularly receptive to theories that placed the blame for the South’s many problems on Southern Italians’ own inborn brutishness. The decades following Unification saw the nascent fields of criminal anthropology and psychiatry establish themselves in the universities of Northern Italy; implementing the pseudosciences of phrenology and anthropometry in their search for evolutionary remnants of an arrested stage of human development manifested in the people of the Mezzogiorno, they used various instruments to measure human skulls, ears, foreheads, jaws, arms, and other body parts, catalogued these, and correlated them with undesirable behavioral characteristics, inventing in the process a Southern Italian race entirely separate from and unrelated to a superior Northern race and officially confirming the biological origins of Southern “savagery.” Read more »

American Snowflakes: Banning Books and Beer Boycotts

by Mark Harvey

Censorship is the strongest drive in human nature; sex is a weak second. –Phil Kerby

A Big Moon Cake for Little Star by Grace Lin

Here’s a book that could really harm your child: A Big Mooncake for Little Star. The title itself promises dark political theories of socialism, sexual deviance, and a character-corroding leitmotif. Thank goodness some astute parents saw the danger of the book and got it on a banned-books list.

Here’s the summary of the book’s plot: Little Star, who is a cute little girl, has a mother who likes to bake. She bakes a big moon cake and puts it into the night sky to cool. She asks Little Star not to eat the cake while it cools. The cake looks like the moon and Little Star can’t resist its deliciousness. So night after night, despite her best intentions to leave the cake alone, she tiptoes into the night sky and nibbles away at the cake. The cake shrinks like a waning moon—from full circle to thin crescent–until there are only crumbs left. The mother discovers that her daughter ate the big mooncake and gently admonishes her. Then the two decide to make another cake together.

That’s the entirety of the book. It’s beautifully illustrated and won the Caldecott Medal, one of the most prestigious awards for children’s books. Full disclosure, I had to know what happened to the mooncake and couldn’t put the book down. But it’s definitely something children should not be exposed to. I’m not exactly sure why but if the book was banned, it was banned for a good reason and would surely set children on a dangerous life course. Mooncake is probably shorthand for moonbeam and moonbeam has a vague reference to hippy culture so maybe that’s it. Read the book to your five-year-old and the next thing you know she’s out on the road selling marijuana! Read more »

Could Be Worse (Part Two)

by Mike Bendzela

Brain MRI from Public Domain.

[Part One of this essay can be found here.]

Alexia, Redux

Throughout the winter of 2017, as he recovered from the stroke, Don went through a battery of therapies, including walking on a treadmill with and without handrails; navigating the winding corridors of the rehab center and having to find his way back to where he started; taking apart and putting back together block puzzles; scanning a large computer screen for numbered sequences.

I was invited to accompany him to his reading therapy sessions because his gay therapist got such a kick out of us. He would spend the first few minutes asking us about life on the farm. He wanted to know about milking cows and slopping pigs, shoveling shit, wringing the necks of unwanted roosters. Two husbands husbanding, har, har. He even devised a few bucolic reading exercises for Don.

Once the reading therapy began, it was painful to watch. Don would stare at the page upon which the therapist had printed a sentence in block letters:

IT WAS ON THE PIG.

The forefinger of Don’s left hand worked furiously as he struggled to recognize the words, like how I used to count on my fingers in math class. He had discovered he could bypass the damaged areas of his brain by transferring the task of letter recognition to his finger. Air writing, as it were. He eventually got around to naming letters without using his finger as a crutch. Read more »

The Future of Medicine: When Doctors Unionize

by Carol A Westbrook

Trucks in a traffic jam on US81

It was the last straw.  “We’re transferring you, Dr. Westbrook,” my Medical Director said to me.

“One of our offices in another town is desperately in need of a Hematologist, ever since Dr. Paul died,” he continued, “and you are the best hematologist on our staff,” he said, trying to cajole me with flattery.

“But I don’t want to be transferred. I really like working here,” I said. “I have a nice practice, which I built up over the last three years since I started here. I really like my patients and have a good rapport with them. Furthermore, I feel I am part of the community now.”

“Don’t worry. We will assign your patients to one of our other doctors, “he said, in a rather cold-blooded tone. It was no consolation at all.

“Do I have a choice? “I asked bluntly.

“No, not if you want to get paid. You can either transfer, or lose your job,” he said. The Director knew that I could be fired without cause, at the discretion of any of my superiors.

I gave it some thought and reviewed my options. The opportunity to practice full-time Hematology was actually appealing; it’s a difficult specialty, and I enjoy the challenge. And there would be no hospital call, either. But on the downside, it  would mean a long commute—it’s thirty miles away from home, traveling on a crowded interstate, US81 with a lot of speeding truck traffic and three mountain ranges to cross. Most importantly, I would have to leave a practice that I’d built up over three years, with many dear patients I hated to leave behind. If I refused the transfer, I would lose my job, and I doubted if I would be able to find another position at age 64. It would still be a year until I would qualify for Medicare and for full Social Security benefits. I would have to stick it out. Read more »

Sunday, May 7, 2023

Perambulating

Bastian Fox Phelan in the Sydney Review of Books:

For the first six weeks I can’t walk further than a few hundred metres. I feel like I’m practicing a walking meditation without experiencing the mental effects of this exercise – to focus on one activity, to centre myself. I’ve just had a baby; I am profoundly de-centred. In my current state, I can’t push the pram, or wear my new baby on my body, or drive a car. When I lie down at night, it feels like all my organs will spill onto the bed. Other fluids seep out – milk, tears. My body produces these things, and I cannot control them. I had not planned for the baby to exit my body in the way that she did, and for some reason this causes me more pain than the scar that now bisects my abdomen.

More here.

How we decided alcohol was a health boon in the ’90s—and how it all fell apart

Tim Requarth in Slate:

In 1991 an academic debate spilled out of ivory towers and into the popular imagination. That year, Serge Renaud, a celebrated and charismatic alcohol researcher at the French National Institute for Health and Medical Research—who also hailed from a winemaking family in Bordeaux—made a fateful appearance on 60 Minutes. Asked why the French had lower rates of cardiovascular disease than Americans did, even though people in both countries consumed high-fat diets, Renaud replied, without missing a beat, “The consumption of alcohol.” Renaud suspected that the so-called French paradox could be explained by the red wine at French dinner tables.

The French paradox quickly found a receptive audience. The day after the episode aired, according to an account in the food magazine the Valley Table, all U.S. airlines ran out of red wine. For the next month, red wine sales in the U.S. spiked by 44 percent. When the show was re-aired in 1992, sales spiked again, by 49 percent, and stayed elevated for years.

More here.

More radical and practical than Stoicism – discover Shugendō

Tim Bunting in Psyche:

Wearing the white robes that are used to dress the dead in Japan, I bow my head deeply as drums are beaten and conch shells are blown – reminders that the first rite of my yamabushi ascetic training is beginning. My funeral is starting. Along with a small group of uninitiated who are also preparing to ‘die’, I start a symbolic pilgrimage into the afterlife, descending the slopes of Mount Haguro, a cedar-covered mountain in Japan’s northern Yamagata Prefecture.

Mt Haguro, along with and nearby Mt Gassan and Mt Yudono, form the Dewa Sanzan, the three sacred mountains of Dewa, as the region was once called. For yamabushi, and the Shugendō tradition they practise, there are few holier places. Mountain ascetics have been practising rituals and magic on Dewa Sanzan since at least the 8th or 9th century, and perhaps much longer, back to a point in history where myth and memory begin to blur.

More here.

‘Statistically impossible’ heat extremes are here

Nicholas Leach in The Conversation:

In the summer of 2021, Canada’s all-time temperature record was smashed by almost 5℃. Its new record of 49.6℃ is hotter than anything ever recorded in Spain, Turkey or indeed anywhere in Europe.

The record was set in Lytton, a small village a few hours’ drive from Vancouver, in a part of the world that doesn’t really look like it should experience such temperatures.

Lytton was the peak of a heatwave that hit the Pacific Northwest of the US and Canada that summer and left many scientists shocked. From a purely statistical point of view, it should have been impossible.

More here.