June 29, 2011
St Martin’s stomach
Alexis St Martin was one of the 19th century’s most important scientific guinea pigs. In 1822, the illiterate young French-Canadian was working as a ‘voyageur’ for John Jacob Astor’s fur-trading company in northern Michigan. He was hanging out with a bunch of rowdies in the company store when a shotgun accidentally went off and he was hit below his left nipple. The injury was serious and likely to be fatal – his half-digested breakfast was pouring out of the wound from his perforated stomach, along with bits of the stomach itself – but a US army surgeon called William Beaumont was nevertheless sent for. Beaumont was pessimistic, but he cleaned the wound as best he could and was amazed the next day to find his patient still alive. It was touch and go for almost a year: St Martin survived, though with a gastric fistula about two and a half inches in circumference. It was now possible for Beaumont to peer into St Martin’s stomach, to insert his forefinger into it, to introduce muslin bags containing bits of food and to retrieve them whenever he wanted. Human digestion had become visible. Beaumont took over St Martin’s care when charity support ran out, and over the next ten years the patient lived intermittently with the doctor, as both his domestic servant and a contractually paid experimental object. St Martin’s fistula was soon to become one of the modern world’s most celebrated peepshows.more from Steven Shapin at the LRB here.
Posted by Morgan Meis at 08:48 AM | Permalink






















Comments
This is a most interesting post because it highlights the relative importance to life of the organ of digestion.
Of course, living without a stomach it’s not only possible, but has been already demonstrated by some. http://www.bbc.co.uk/news/health-10786205
However, the stomach, for its survival significance, and for its myriad of (yet to be understood functions), maintains close, but if ill understood, humoral communications with the brain.
‘Writing in 1840, an English physician had it as a matter of course that ‘a most intimate sympathy exists between the Stomach and the Brain’. We can now ratify this premonitory assertion (Larocca, FEF: Gastroplastía y lobotomía: La conexión entre el estómago y el cerebro - La serotonina reexaminada en http://www.monografias.com/trabajos67/cirugia-gastroplastica-lobotomia/cirugia-gastroplastica-lobotomia.shtml?monosearch)
Walter Cannon was not as much interested on the physiology of digestion as he was in finding the origin of the perception of hunger.
His paper, published with Arthur Washburn in 1912 established erroneously that hunger resulted from the peristalsis of the stomach and not from the lowering of glucose levels in the blood and other mechanisms now sufficiently understood.
The question that yet remains to be settled is, how (if it in realty does) the poorly understood physiology of the stomach could be relevant to our understanding of the course (and curse) of obesity?
Thanks for posting
Posted by: Felix E F Larocca MD | Jun 29, 2011 1:42:22 PM
Post a comment