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August 19, 2008

The Danger of Stress

From Scientific American:

Stress You probably think you're doing everything you can to stay healthy: you get lots of sleep, exercise regularly and try to avoid fried foods. But you may be forgetting one important thing. Relax! Stress has a bigger impact on your health than you might realize, according to research presented yesterday at the annual conference of the American Psychological Association in Boston.

Ohio State University psychologist Janice Kiecolt-Glaser and her partner, Ronald Glaser, an OSU virologist and immunologist, have spent 20-odd years researching how stress affects the immune system, and they have made some startling discoveries. An easy example comes from their work with caregivers, people who look after chronically ailing spouses or parents (no one would argue that this role is quite stressful). In one experiment, Kiecolt-Glaser and her colleagues administered flu vaccines to caregivers and control subjects and compared the numbers of antibodies—proteins involved in immune reactions—that the two groups produced in response. Only 38 percent of the caregivers produced what is considered an adequate antibody response compared to 66 percent of their relaxed counterparts, suggesting that the caregivers' immune systems weren't doing their jobs very well—and that the stress of caregiving ultimately put them at an increased risk of infection.

More here.

Posted by Azra Raza at 07:32 AM | Permalink

Comments

A different article from Scientific American was part of a Psych 201 class I took in 1968. "The Executive Monkey" by Joseph V. Brady described how two monkeys hooked up in identical harnesses were given identical electrical shocks, but one of them, called the "executive", had access to a bar to make the electricity stop.

When the shocks came both endured the same effect, until the executive monkey gave them both relief. We know which animal developed ulcers and other physical symptoms of stress.

It was a classic experiment that would no longer be politically correct in the world of PETA principles, but I see someone has put an article about it into Wikipedia.

Posted by: John Ballard | Aug 19, 2008 8:46:35 AM

Yes and fine...

But ulcers ain't gotten that way!

Posted by: Felix E F Larocca MD | Aug 19, 2008 10:25:40 PM

You're right. I remember reading that ulcers are caused by colonies of microbes in the digestive system which are responsive to the right medicines. I guess they drew the wrong conclusions from monkeys. Who knew?

Just this morning I heard that further investigations into the mortality of victims of the famous 1918 flu virus indicate that bacterial infections were more to blame for the death rate than the flu virus itself. As one contemporary said at the time "The flu condemns, but it is a secondary infection that kills." Antibiotics were to come later.

Somewhere in there is a glimmer of hope that things may not be as bad as we think...

I'm just glad the researchers keep finding new stuff.

Posted by: John Ballard | Aug 20, 2008 3:33:49 PM

John, along these lines Barry J Marshall and J Robin Warren shared a Nobel Prize in 2005 for having discovered the effect of a bacteriumn that produces peptic ulcers.

Posted by: Felix E F Larocca MD | Aug 20, 2008 9:18:19 PM

...bacterial infections were more to blame for the death rate than the flu virus itself.

A good factoid for the next time a Doc balks at giving you an antibiotic when you have the flu

Posted by: Carlos | Aug 20, 2008 11:23:31 PM

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